Alzheimer's Research - a glimmer of hope

An experimental drug cleared protein buildup in the brains of people with mild Alzheimer's disease and slowed their mental decline, the results of a preliminary trial showed Wednesday.

The outcome raised hopes that a treatment may finally be within reach for the memory- and independence-robbing disease, but experts cautioned against overplaying the findings.

The drug, aducanumab, is only the latest antibody to show promise in an early, Phase I drug trial, they said. Others ended up disappointing in the decisive Phase III efficacy test.

"Although potentially this is an exciting story, it is important to temper any excitement with considerable caution," said Robert Howard, a professor of old age psychiatry at University College London.

"It would be premature to conclude that this is likely to represent an effective treatment for Alzheimer's disease."

Researchers in the United States and Switzerland tested aducanumab, developed by biotech firm Biogen, on 165 people with early-stage Alzheimer's disease for a period of one year.

Some were given a monthly injection of the antibody, and others a placebo or dummy drug.

In the brains of those given the treatment, there was an "almost complete clearance" of so-called amyloid plaques, the researchers reported.

Amyloids are sticky proteins that clump together in deposits -- one of the mechanisms suspected of causing Alzheimer's.

"The effect of the antibody is very impressive," said Roger Nitsch, a professor at the University of Zurich's Institute for Regenerative Medicine, who co-authored the study.

- 'Now is the time' -

After one year of treatment, "practically no beta-amyloid plaques could be detected in patients who received the highest dose," said a university statement.

And while the trial was not designed to test drug efficacy, the team did observe slower onset of symptoms in treated patients.

This supported the hypothesis that amyloid plaques are indeed what cause Alzheimer's, the researchers said, but further tests are required to prove this once and for all.

"Indeed, confirmation that anti-AB (amyloid-beta) treatment slows cognitive decline would be a game-changer for how we understand, treat and prevent Alzheimer's disease," commented Eric Reiman at the Banner Alzheimer's Institue in Phoenix, Arizona.

"Now is the time to find out."

The drug did have side-effects, however, including fluid buildup on the brain, and headaches.

Alzheimer's disease is the most common form of dementia, which the World Health Organisation (WHO) says affects nearly 50 million people worldwide -- with some 7.7 million new cases diagnosed per year.

Old age is the major risk factor, and there is no prevention or effective treatment for Alzheimer's symptoms, which include memory loss and disorientation, as well as anxiety and aggressive behaviour.

Like actor Gene Wilder, who passed away on Monday, people do not die of Alzheimer's itself but complications which can include infections or malnutrition.

Last year, drug-maker Eli Lilly said the drug solanezumab, also an antibody, showed promise when given to people in the early stages of Alzheimer's.

Results from further testing with both drugs will be hotly anticipated in the months to come.

Outside experts expressed cautious optimism about the new study, published in the journal Nature.

"Let's keep our fingers crossed for success in the next steps," said neuroscience professor Richard Morris from the University of Edinburgh.

    

 

 

Gene Wilder's Death: How Do People Die from Alzheimer's?

Legendary comedic actor Gene Wilder has died at age 83 from complications of Alzheimer's disease, his family announced today. But what exactly does it mean to die from Alzheimer's?

Although Alzheimer's disease shortens people's life spans, it is usually not the direct cause of a person's death, according to the Alzheimer's society , a charity in the United Kingdom for people with dementia. Rather, people die from complications from the illness, such as infections or blood clots.

Alzheimer's is a progressive brain disease in which abnormal protein deposits build up in the brain, causing brain cells to die. The illness is best known for causing memory loss, but it also has other debilitating effects on the body, and can affect people's ability to move and eat by the Alzheimer's patients may have difficulty swallowing, and they may inhale food, which can result in aspiration pneumonia, Dr. Marc L. Gordon, chief of neurology at Zucker Hillside Hospital in Queens, New York, who was not involved in Wilder's care, told Live Science,  in a 2014 interview. Pneumonia is listed as the cause of death in as many as two-thirds of deaths of patients with dementia, according to the Alzheimer's Society.

Alzheimer's patients may also become bedridden, which can increase their risk of fatal blood clots, Gordon said.

Weight loss and other complications from Alzheimer's can also lead to a weakened immune system, the Alzheimer's Society says. This increases a person's susceptibility to potentially life-threatening infections, according to the National Institute on Aging.

These effects on the body are most pronounced in the advanced stage of the disease, which lasts about 1.5 to 2 years, on average, according to the NIH.

Alzheimer's disease is the sixth-leading cause of death in the United States, according to the Centers for Disease Control and Prevention. In 2013, nearly 85,000 people in the United States died from the disease, the CDC says.

However, death from Alzheimer's Disease,  may be underestimated, because death certificates often list pneumonia or another complication as the cause of death, rather than the underlying Alzheimer's, according to a 2014 study. The study estimated that as many as 500,000 people in the United States died from Alzheimer's in 2010.  There is no cure for this disease

Original article on Live Science.

 

 

Alzheimer's Disease - 5 Million Americans are Living with the Disease

There are 24 million people in the world with Alzheimer's Disease or other forms of dementia, and this number is growing rapidly. In fact, it's expected to triple to 81 million by 2040. Here's what you should know about Alzheimer's disease and dementia life expectancy

How Common is Alzheimer's Disease?

In 2015, over 5 million Americans were living with Alzheimer's. This included about 5 million people over the age of 65, and about 200,000 people with earlier-onset disease.

One in nine people 65 and older has Alzheimer's disease, and about 30 percent of Americans over the age of 85 has the disease.

Eighty-one percent of people with Alzheimer's are 75 years old or older.

Alzheimer's Disease Life Expectancy

Figuring out the impact of Alzheimer’s disease on life expectancy and longevity is complicated, as people are normally older when they are diagnosed with Alzheimer’s disease, and they may have multiple conditions impacting their life expectancy. However, here's what we do know about Alzheimer's disease and life expectancy.

Alzheimer's disease is one of the top 10 causes of death in the United States. According to the Alzheimer's Foundation of America, the disease usually progresses over anywhere from two to 20 years. People diagnosed with Alzheimer's typically live an average of eight to 10 years from their time of diagnosis.

In one study, researchers at the Johns Hopkins Bloomberg School of Public Health found that having late-stage Alzh

 This 8 percent increase in risk remains constant with aging and is added to other risk factors, such as heart disease.

Factors That Determine Longevity

One study found that the main factors that determine how long a person lives after being diagnosed with Alzheimer's disease or another form of dementia are age, gender, and level of disability.

Here are the main research findings:

  • Women lived an average of 4.6 years after diagnosis, men lived 4.1 years.
  • People diagnosed when under age 70 lived 10.7 years compared to 3.8 years for people over 90 when diagnosed.
  • Patients who were frail at the time of diagnosis did not live as long, even after adjusting for age.
  • Overall, the average survival time for someone in the study diagnosed with Alzheimer's disease or dementia was 4.5 years.

Improving Quality of Life for Your Loved One

In the early stages of Alzheimer's disease, cognitive impairment is not the only determinant of quality of life. While you can't change factors such as age at diagnosis or gender, research shows that the care that a person receives impacts life expectancy. Be sure that you explore options when it comes to creating a care plan for a loved one diagnosed with Alzheimer's disease and take advantage of any support groups or other resources that may help.

The extent to which a person with the disease can maintain his or her social relationships can also play a large role.

Patients should talk with their doctor  for strategies to cope with social situations. In addition, maintaining household responsibilities for as long as able can help improve quality of life. In later stages, a patient's needs may change, and it is important for a caregiver to know how to care for themselves in addition to their loved one.

Preventing Alzheimer’s Disease and Dementia

There have been many studies looking into the use of puzzles  to help delay or prevent Alzheimer’s disease and dementia. A famous study of nuns showed that the individuals most curious and engaged mentally in the world had less Alzheimer’s disease and dementia. Try these top ways to exercise your brain.

Sources:

Alzheimer's Foundation of America. (n.d.). Alzheimer's Disease Life Expectancy. Retrieved February 27, 2016

Johnson, Elizabeth; Brookmeyer, Ron; and Ziegler-Graham, Kathryn (2007) "Modeling the Effect of Alzheimer's Disease on Mortality," The International Journal of Biostatistics: Vol. 3 : Iss. 1, Article 13.

Xie J, Brayne C, Matthews FE; and the Medical Research Council Cognitive Function and Ageing Study collaborators. Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up. BMJ. 2008 Jan 10.

 

 

How to Approach Your Loved One When They are Aggitated and Anxiety Ridden

  • Try de-cluttering the environment.

  • Learn trigger points and avoid them in the future.

  • Create a calm space.

  • Be aware of what is in your loved one’s line of vision.

  • Make sure your loved one has enough light. Low lighting could trigger agitation and anxiety.

  • Create a change of scenery.

  • Try a gentle touch.

  • Your loving voice can provide comfort when your family member is agitated.

  • Know your loved one’s preferences and routines—it can make a big difference.

  • Refocus the person’s attention.

  • Try offering comfort from a beloved family pet or grandchildren.

  • Fresh air and nature can have a positive impact.

  • Everybody likes a good laugh.

  • Give simple tasks to make your loved one feel useful.

  • Provide something familiar—it can be calming.

  • If your family member is pacing, ask if you could join in the walk.

  • If your loved one gets flustered when faced with decisions, simplify choices.

  • Be prepared

resource:  HelpforAlzheimersfamililes.com - Home Instead Senior Care

News from the Alzheimer's Association

July 6, 2016


Dear Colleague,

I am excited to share with you more encouraging news out of Washington, D.C. Today, the House Labor-HHS Appropriations Subcommittee announced a $350 million increase for Alzheimer’s disease research at the National Institutes of Health (NIH). This comes just a few weeks after I was able to share with you the historic news that the Senate Appropriations Committee approved a $400 million increase.

With this proposed increase, both the House and the Senate have now proposed increases that are $50 million above what they proposed last summer. We are confident that, just like last year, our champions in the House and Senate will work hard to deliver the best possible final increase that they can, starting from these two proposals.

We will keep you informed, as the appropriations process continues to unfold. As you will likely recall, in June 2015 we were thrilled to share news of the historic $350 million increase, which was ultimately signed into law in December 2015 for FY2016.

It was just five years ago when Alzheimer's disease research funding at the NIH stood at only $448 million per year. With last year’s historic action Alzheimer’s disease research funding reached $991 million for the FY2016 budget. If another step of this magnitude is signed into law, we will surpass the $1.3 billion mark.

We are very proud of and thankful to our partners.This monumental growth would not have happened without your tireless work and support of of the Alzheimer's Association and the Alzheimer's Impact Movement. Working together going forward, we will accomplish even more, as we succeed in delivering our mission and in realizing our vision even sooner.

Thank you.

Sincerely,
Maria

 

Dementia and Genetics

 

It’s A Family Affair

If you follow Alzheimer’s research, you may have heard of a village in Colombia called Yarumal, population of over 5000. Yarumal has the largest known population affected by Alzheimer’s Disease.

More than 5,000 people in Yarumal who share the same blood line are affected. Genetic mutation and a linked bloodline means that most village residents will have dementia by the age of 40. In the following interview, Dr. Ashok Patel, Medical Director of the Memory and Aging Center of New Jersey, discusses the importance of current research in Yarumal.

Why is Yarumal so important to researchers? Well, for one, it has the highest per capita rate of Alzheimer’s Disease in the world. Twenty-five extended families in Yarumal are affected. These families, who all share the bloodline of one 350 year-old Spanish conquistador, have provided information and tissue for studies spanning more than 30 years. This research has sparked interest and hope among families, physicians and researchers across the globe.

What’s next in the assault against Alzheimer’s? The Alzheimer’s Prevention Initiative is conducting drug trials to determine if giving treatment before the onset of dementia can lead to preventing Alzheimer’s. The families in Yarumal have inherited a genetic mutation that almost guarantees that they will develop Alzheimer’s. This makes them the perfect recipients for such new treatments.

Is there a link between early onset and late-onset Alzheimer’s? Not necessarily. There are differences in the form of inheritance of early and late-onset Alzheimer's, as well as in the pace of its progression, and so on. But despite these differences, the brain atrophy--the shrinkage or decay of the brain--in both types of the diseases were found to be identical. I believe that millions of people may benefit from more effective Alzheimer’s treatments in the future as a result of this ongoing research.

Despite the differences between the inherited form of Alzheimer’s and the more common type that mainly affects the elderly, the brain lesions in both types of the diseases were found to be identical. I believe that millions of people may benefit from more effective Alzheimer’s treatments in the future as a result of this ongoing research.

Are you concerned about memory loss? The Memory and Aging Center of New Jersey offers thorough memory evaluations to determine the current status of memory and to find the right treatment option for the patient. We provide the latest advanced testing and screening for Alzheimer’s. We conduct the test for the APOE gene and perform scans to detect amyloid plaques. Contact us for more information or to schedule a free evaluation.

More information about The Alzheimer’s Prevention Initiative can be found in the July 2014 issue of Alzheimer’s & Dementia.

 

 

Communicating with a Person with Dementia Can Be Very Difficult

While I was shopping over the weekend, I overheard a woman scolding an older woman, who I am guessing was her mother.  Being in healthcare these past 10 years with a concentration in Alzheimer's/Dementia, it was clear to me that the older woman had dementia.  I was saddened,  by the way she was being treated, but I know how overwhelming and taxing it can be on the caregiver of an Alzheimer's patient. I thought to myself this lady needs a break. 

 Here are some tips on communicating with a person with Dementia:

  • Respond with affection and reassurance - People with dementia usually feel confused and scared
  • Listen with your ears and eyes and above all your heart - be patient
  • Be positive
  • Speak clearly and slowly
  • Ask simple questions and not to many
  • Try and relate the good old days to the current situation - remembering the past is often very soothing to a person with dementia.
  • Do your best to redirect and distract your loved one especially if they are aggressive or agitated.

Most importantly, take a break.  Ask a friend or family member to give you an hour or two to yourself, which in the long run will help make caregiving less stressful and will help you get along better with your loved one.  God Bless


Ginger Girl

Happy Father's Day

My father passed away 17 years ago at the very young age of 59.  Father's day and my birthday always falls around the same time.  My birthday  is June 18th.   We always celebrated both days as one.  I can remember there were  lots of greeting cards around the house for that one week in June.  Dad and I used to guess who would get the most cards or gifts each year.  I always won.  So now I visit St. Anne's Cemetery on Father's Day to talk to my dad and reflect.  He must get sick and tired of listening to me :)   I can almost guarantee that some time between Father's Day and my birthday or vice versa, which ever comes first, I will see a cardinal.  It's my dad's way of saying "Happy Birthday Kid"!  Happy Father's Day!!!

 

Ginger Girl

Imagine Living Life in Peace

 

"Imagine"

John Lennon
 

Imagine there's no heaven
It's easy if you try
No hell below us
Above us only sky
Imagine all the people
Living for today... Aha-ah...

Imagine there's no countries
It isn't hard to do
Nothing to kill or die for
And no religion too
Imagine all the people
Living life in peace... You,..

You may say I'm a dreamer
But I'm not the only one
I hope someday you'll join us
And the world will be as one

Imagine no possessions
I wonder if you can
No need for greed or hunger
A brotherhood of man
Imagine all the people
Sharing all the world... You,..

You may say I'm a dreamer
But I'm not the only one
I hope someday you'll join us
And the world will be as one



In the Living Years

As I ready my house for my family and friends, I heard "The Living Years", by Mike and The Mechanics, on one of the tv music channels. Wow! I sat down with Mr Clean and the Scrubbing Bubbles and bawled my eyes out. Such powerful words!  My youngest daughter Jules has her 8th grade dance tonight and both girls graduate this week! So many emotions for me coupled with the tragedy and the loss of all those poor souls in Orlando, who had no idea what was in store for them that night! If we are breathing, we are blessed! Do whatever makes you happy. I  guess I'll go light on the mascara this week and most definately cherish these special times with my girls :)  Here is the video - In the Living Years

https://www.youtube.com/watch?v=uGDA0Hecw1k

 

Ginger Girl

 

 

Latest News in Alzheimer's Research - Long Term Memory Test & Brain Scan

People with Alzheimer's disease could benefit from earlier diagnosis if a long-term memory test combined with a brain scan were carried out, a study suggests.

Scientists say testing memory over a long timescale reveals early deficits in the brain's ability to remember. These are not detected by checks for short-term forgetfulness, which is the current practice for diagnosis.

The study also suggests that a brain scan in combination with a memory test could identify early abnormalities in the brain activity of Alzheimer's patients that would be otherwise undetected.

Researchers say that the type of memory loss revealed by such tests could potentially be reversed by the development of new treatments.

A team at the University of Edinburgh, in collaboration with colleagues in the US, studied long-term memory in young mice, some of which had the equivalent of very early stage Alzheimer's disease, and some of which were healthy.

Scientists taught both groups of mice to locate a hidden platform in a pool filled with water, using signs on the wall of the room to navigate.

The results showed that when tested shortly after the initial task, both groups of mice were able to remember the way to the platform.

However, when tested one week later, the mice in the Alzheimer's group had significantly more difficulty in remembering the route.

Tests revealed that brain activity was normal in both groups of mice at this young age, when no task was involved.

However, the brain activity in the Alzheimer's group was significantly decreased compared with the healthy mice when tested as they tried to remember the way to the platform.

Scientists say the results show that when short-term memory is used to diagnose Alzheimer's disease -- as is currently the case -- it may not reveal the true extent of memory loss at the onset of the condition.

The team says that by testing long-term memory, it may be possible to detect the earliest signs of Alzheimer's disease and offer interventions sooner.

Professor Richard Morris, who led the research at the University of Edinburgh, said: "We recognise that tests with animals must be interpreted with caution, but the use of these genetic models in conjunction with appropriate testing is pointing at an important dimension of early diagnosis."

Dr Vassilios Beglopoulos, of the University of Edinburgh's Centre for Cognitive and Neural Systems, said: "It is widely acknowledged that earlier intervention is needed to effectively treat Alzheimer's disease, and better diagnostic tools are needed for that. We believe that our approach could make a significant contribution."

Story Source:

The above post is reprinted from materials provided by University of Edinburgh. Note: Materials may be edited for content and length

You Can't Help Someone Who is Not Willing to Help Themselves...End of Story

 

Unfortunately, no matter what you do, no matter what you say, if a person does not want help or does not feel they need help, there is really is not much more you can do!.  I have a friend Suzanne,  whose ex husband is a weekend warrior - that is,  he drinks heavily on the weekends and sobers upMonday through Thursday.   During his weekend binges, he creates havoc with family and friends.  I feel bad for Suzanne's children, who have to put up with his nonsense via phone calls, text messages and email.   There has to come a point and time, where she and everyone else has to walk away.  He will never change unless he wants to change.  She will only kill herself trying.  Kids are resilient, they will be ok.   I told her instead of throwing a Life Preserver out to him, as he sits on his boat with a hole that only he created, she and her children should hoist their sails and enjoy life!

 

Ginger Girl

Great News from the Alzheimer's Association!! We Could be Closer to a Cure

June 6, 2016

Dear Colleague,

As a researcher or healthcare professional, you understand how critical research funding is to our mission at the Alzheimer's Association to prevent, slow and, ultimately, stop this deadly disease.

This is why it is my great pleasure to share this historic news with you. This morning, the Senate Labor-HHS Appropriations Subcommittee informed us that they will propose an additional $400 million increase in Alzheimer's research funding for FY2017. If approved and signed into law, this would be in addition to the historic $350 million increase signed into law at the close of 2016.

For the Alzheimer's Association's statement on today's very important news, please visit the following link:
http://www.alz.org/news_and_events_alz_funding_on_path_for_additional_400_million.asp

An article today profiling the news and one of our strongest congressional champions appeared this afternoon in the Boston Globe's publication, STAT:
http://www.statnews.com/2015/12/11/tom-cole-nih-funding-alzheimers/

Let me conclude by thanking you for faithfully and tirelessly supporting all of these efforts, directly and indirectly, through the Alzheimer's Association and the Alzheimer's Impact Movement. Working together going forward, we will accomplish even more, through all elements of our strategic plan, as we succeed in delivering our mission and in realizing our vision even sooner.

Sincerely,

 

Maria C. Carrillo, Ph.D.
Chief Science Officer

 

It's June 1st - National Go Barefoot Day

I can't believe its June 1st already, Ihave such a busy month ahead of me.  Both my girls graduate, one from grammar school and one from high school, then there is my birthday, Father's day and vacation.  I am already exhausted.   So I am trying to get ahead with my event planning for work, which brought be to googling  "What day of the week is Flag Day?"  and hundreds of "June Observances" popped up.  For instance today, June 1st is National Barefoot Day, Heimlich Maneuver Day, Say Something Nice Day, Stand for Children Day.  Wow!!, who comes up with this stuff.  When I woke up this morning to me it was Wednesday, the first of June - who knew it was ok to forget my shoes and go barefoot today!   Tomorrow, June 2nd is National Bubba Day, National Tailor Day and Leave the Office Early Day...Sounds good to me!

 

Ginger Girl

Are You Prepared?

When I leave my house in disarray and head out for the day, I sometimes think "What if something happens to me today and people go to my house and see the confusion!  Then my mind starts racing to my closet, my drawers, personal paperwork - Oh My - I'm not prepared!!  I know my girls will be able to find the basics - but I really need to finish up my "Jackie Book".   I have already recorded things like my social security number, banking information and life insurance policy but there is still more I should record.  Here's my check list :

  • Will
  • Advanced Directives
  • Health Insurance Cards
  • Medications List
  • Banking Information
  • Health Insurance Cards
  • Social Security Card
  • Doctors
  • Creditors
  • Bill Payment Information
  • Car Insurance
  • Attorney's Name
  • Funeral Home - Cemetery Information
  • Final Wishes

I've gathered a lot of the this information but I still have more work to do to get my "Jackie Book" finished...and just think I started thinking about this again - because my house was a mess!  I think I'll clean when I get home today.

 

Ginger Girl

Please Don't Say "It's To Hot"

I am looking forward to leaving the office today and I am anticipating that feeling of walking out of an air conditioned building and getting hit by the heat.  My phone is reading 88 degrees in Toms River.  Finally!  I love this weather as most people probably do.  But I am 100% positive that somewhere along my travels today, I will hear "It's to hot" or "This weather is disgusting - way to hot" and so on.  You may hear me say that in mid July or August, but no way.. not today.  With most of May being rain filled and damp, today's temperatures aremost welcomed.   Memorial Day Weekendhere at the Jersey Shore - looks like it's going to be good one!   If I hear someone say  "It's to hot", these next few days, I will be quick to remind them that Christmas is just 7 months away from today.....I can bet they will be wishing it was "to hot" outside instead of asking for "hot" chocolate on Christmas morning.

 

Ginger Girl

Memories of The Preakness Gone By

Tomorrow is the 141st running of the Preakness Stakes in Pimlico, Maryland.  And tomorrow I will be wishing I was there.   When I began my freshman year at Towson State College (Towson University) in 1983, I quickly learned some very important things about Marylanders....you have to enjoy sitting at a picnic table that is covered in brown paper with dozens of Maryland crabs thrown about (complete with Old Bay Seasoning), pitchers of beers and loving every bite of crab meat - this was not a problem for me!    Rooting for the Baltimore Orioles was another, but the one "Marylander" thing you have to do at least once in your life (but really a lot more) is to attend the Preakness (the 2nd leg of the triple crown in horse racing).  Well,  I attended every year during my time in Maryland and a few years after I moved back to New Jersey.   By 10am, I was sitting in the infield of the track (they no longer allow this) with a hot coffee, just joking with a cold beer and a Black Eyed Susan (signature drink of the race), we would play games, dance, eat and really have the time of our lives.  The actual signature race - the Preakness, went off around 5:30pm, so exciting to watch. There was always the one guy who missed the big race due to his day long shenanigans and needing a siesta in the late afternoon.   I always loved seeing the ladies in the stands with their beautiful hats.   But once again, I will sit in my living room, make myself a Black Eyed Susan and watch the race, reliving all my happy memories in the infield of Pimlico Racetrack.  I will be cheering on Awesome Speed - he is a Jersey Boy - from Colts Neck, NJ.  No doubt, I will return to Pimlico at least one time before I leave this planet - its on my After 50 Bucket List!  I can't wait

 

Ginger Girl

Alzheimer's Disease is Not Just for the Elderly - Early Onset Symptoms

Early Onset Alzheimers Symptoms

Alzheimers disease is most commonly a disease affecting people above the age of 65. In some rare circumstances, about 5% of the time, it has been known to affect younger people, even in their 30s. This form of the disease is referred to as early onset Alzheimers.

Because Alzheimers disease is associated with older people, early onset Alzheimers symptoms are quite often dismissed or put down to another cause such as stress. However, it is exceeding important to seek medical advice if you think you or a loved one are experiencing early onset Alzheimers symptoms.

Early onset Alzheimers symptoms are similar to the symptoms experienced in late onset Alzheimers disease. This form of Alzheimers is often linked to genetics with the mutation of 3 genes thought be responsible. These 3 genes are PSEN1 (presenilin-1), PSEN2 (presenilin-2) and APP (amyloid precursor protein). It is therefore thought that if you have a relative, parent or grandparent, who suffered early onset Alzheimers disease, you have a greater chance of developing this form of the disease.

Genetic testing is carried out on people to find out if they are carriers of the gene mutations. This may be particularly important in order to make decisions as to child bearing, child care and perhaps prepare loved ones for the possibility of dealing with early onset Alzheimers symptoms.

People with Down’s syndrome have also been found to be more susceptible to early onset Alzheimers disease and this is thought to be because they age prematurely.Pl

The early onset Alzheimers symptoms are also divided into early symptoms, progressive symptoms and later symptoms. The earliest symptoms of early onset Alzheimers are poor concentration and forgetfulness. As the disease progresses, an individual will experience impaired thinking and visual skills, memory loss, disorientation, poor judgment and impaired learning ability. Also as the disease progresses, the patient may be prone to frustration and depression.

Later symptoms are the same as those experienced in late onset Alzheimers with a patient needing almost full time care.

As some of the early onset Alzheimers symptoms are similar to other neurological disorders and due to the fact that Alzheimers disease is considered a disease of the elderly, it is quite often misdiagnosed. Doctors may think that a younger person may be suffering from conditions such as drug side effects or drug interactions, infections affecting the brain such as syphilis, encephalitis and meningitis, malnutrition, epilepsy, stroke, ADHD, schizophrenia and brain injury.

The misdiagnosis of early onset Alzheimers symptoms is the main reason this form of the disease is thought to progress more rapidly than the late onset form. This is in part because younger people get diagnosed when the disease has progressed to the middle stage when symptoms are more severe.

Source: Alzheimer's Warning Signs

If you suspect someone you love may be experiencing symptoms or maybe even yourself, please contact our office for a free consultation (732) 244-2299.

 

Growing Up With a very Superstitious Italian Mother

Happy Friday the 13th.  So let's see.. Beware of black cats, don't walk under a ladder and don't open an umbrella in the house...just a few superstitions associated with Friday the 13th.  I have a very, very, very long list of superstitions that was instilled in me from when I was a young girl.  Instilled by my very Italian mother. 

* Never put shoes on the bed, its bad luck, means death will come (same goes for a Hat)

* Never put a loaf of bread upside down on the table

* If you hear a dog howling for more than 3 nights - death is coming

* If you put an article of clothing on inside out - leave it that way

* If a bird flies in the house - death is coming

* Spill the Olive Oil - watch out - death is coming

(Moral of these superstitions...Death is always coming -Shocker!!!)

And so I can go on and on - I can actually write a book.  My Irish father use to laugh at her and roll his eyes,   She is truly committed to these beliefs.   My brother and I would roll our eyes and sometimes put the bread upside down on the table on purpose and wait for to see her reaction.  Sad thing is, at the age of 50, I am just as superstitious as she is and I try not to let the girls see the hair onmy arms stand up when they put their shoes on the bed. 

Italian Mothers they are the best not only are they the best cooks, they keep you on your toes and they teach you how to keep death away for as long as possible!

Ginger Girl